![]() ![]() In veterinary medicine, four dogs with sex hormone-producing adrenal tumors have been reported, and they showed typical clinical signs related to hyperadrenocorticism. Sex hormones, particularly 17-hydroxyprogesterone, are suspected as the cause of atypical Cushing's syndrome. The majority of adrenocortical tumors secreting cortisol induce clinical signs related with hyperadrenocorticism, including polyphagia, polydipsia, polyuria, abdominal distension, and bilateral alopecia. Clinical signs related to an adrenal tumor depend on the hormones secreted. ![]() Non-functional adrenal tumors are not uncommon, and 57% of pheochromocytomas have been reported as non-functional. Functional adrenocortical tumors generally produce cortisol, rarely aldosterone or sex hormones, while medullary tumors produce catecholamines. Adrenal tumors are classified as functional or non-functional.
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